Chemopreventative Effects of Olive Oil and Figs and Date extract by Egyptian Scientists, Al Azhar University

Chemopreventative Effects of Olive Oil and Figs and Date extract by

Egyptian Scientists, Faculty of Science, Al Azhar University Cairo, Egypt.


As salaam alaikum, the following quote and title is taken directly from the vast research document of the following three egyptain scientists. You will have to click the following link to get full paper of the study. It is an excellent study into the possible benefits of combining olive oil, fig and date extract. I am but a humble admirer of their dedication and knowledge. Effects of Olive Oil and Figs and Date extract byive-and-ameliorative-effects-of-some-natural-antioxidants-in-decreasing-the-toxicity-hazards-of-doxorubicin-and-gamma-radiation

The possible protective effects of olive oil with fig and date-palm fruit extracts as natural antioxidants on some biochemical and hematological parameters of rats treated with doxorubicin and γ-radiation


Mohamed Bashandy

  • 9.17
  • Faculty of Science ,Al-Azhar University

Abdallah Hussien Fathy

Samir Abd El-Monem Bashandy

Ahmed Mansour

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References (53)

Abstract and Figures

The present study was designed to determine the possible protective effects of the olive oil (7 g/kg) with fig (1 g/kg) and date-palm fruit (1 g/kg) extracts (OFD) against the toxicity hazards of doxorubicin (DOX) which was used as chemotherapy of cancer and/or γ-radiation which was used as radiotherapy of cancer. The DOX-treated groups were injected with doses of 2.5 mg/kg, i.v., weekly for 4 consecutive weeks (10 mg/kg cumulative doses). Rats of irradiated groups were exposed to whole-body γ-radiation with fractioned doses of 2 Gy weekly for 4 consecutive weeks (8 Gy cumulative doses). The OFD-treated groups were received two weeks pretreatment with OFD and during the experimental period, daily via oral gavages. The DOX-treated and/or irradiated groups recorded depletion of the antioxidant parameters (reduced glutathione (GSH) and nitric oxide (NO)) as well as increased thiobarbituric acid reactive substances (TBARS). Also, we observed alterations of lipid profile parameters (triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)), lipid risk ratios and hematological values (erythrocyte (RBC) count, hemoglobin (Hb) concentration, hematocrit (Hct) percentage, platelet count, total and differential leukocyte (WBC) count) in these groups as compared with control rats. Administration of OFD to DOX-treated and/or irradiated rats significantly ameliorated the oxidative stress markers, lipid profile, risk ratios and the hematological parameters. In conclusion, olive oil with fig and date-palm fruit extracts together could be used synergistically to decrease the bad side effects of chemotherapy and radiotherapy. Keywords: Olive oil; fig fruit extract; date-palm fruit extract; doxorubicin; γ-radiation; oxidative stress; lipid profile; hematological parameters.



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